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Smoking affects efficacy

Time: 2013-07-02 22 : 03Source : Internet
It is known that smoking is harmful to health, but the effects of smoking on its effects are not well known. Studies have shown that there are two main reasons that smoking affects the efficacy of drugs: one is that peripheral blood vessels constrict and the blood pressure rises during smoking, which reduces the absorption of drugs; the other is that harmful components in cigarettes such as nicotine and cigarette tar can occur with drugs The action increases the activity and quantity of enzymes involved in drug metabolism in the liver, thereby accelerating the metabolism of the drug in the body, promoting the excretion of the drug, and reducing the effective concentration of the drug in the blood. According to a survey by a scientist in the United States, only 1.2% to 1.8% of smokers can reach the blood within half an hour after taking the drug, while 21% to 24% can be reached without smoking within half an hour. Studies show that the following types of drugs are affected by smoking:
Cimetidine and ranitidine Smoking can affect the efficacy of the antiulcer drugs cimetidine and ranitidine, which is not conducive to the healing of ulcers. Smokers also have a high relapse rate after stopping taking antiulcer drugs.
Vitamin C Swedish medical scientist Andrei Kad has revealed that a substance in tobacco has a powerful destructive effect on vitamin C. Some people calculate that smoking can reduce the level of vitamin C in the blood by 30%.
Lidocaine Because smoking accelerates the excretion of lidocaine, when a dentist uses lidocaine for anesthetic extraction, the smoker's anesthetic effect is poor, and the incidence of extraction pain is high.
Insulin experiments have shown that insulin absorption decreases by an average of 13% after smoking, and decreases the most in the first 30 minutes after smoking, which can be as high as 31%. This insulin absorption is affected to the extent that the surrounding blood vessels contract after smoking. It can be seen that the effect of smoking on the absorption of subcutaneous insulin is directly related to the vasoconstriction caused by smoking.
Antidepressants Smoking can cause abitirin, de Yumin, imipramine, etc. to decrease in plasma levels, which reduces efficacy.
Heparin Heparin has a shorter half-life and higher clearance in smokers.
Oral contraceptive smoking Smoking can increase the cardiovascular damage of oral contraceptives. Those who smoke more than 15 cigarettes a day over 35 years of age have a greater risk. American scientists believe that compared with non-smokers, smoking and taking contraceptives have a mortality rate of 11.7 times that of the former. It can be seen that oral contraceptives for smokers can promote the occurrence and development of myocardial infarction. Therefore, the instructions for estrogen oral contraceptives produced in the United States have stated that smoking cessation should be stopped during the medication, or other contraceptive methods should be used when smoking.
Aminophylline smoking patients with bronchial wheezing after taking theophylline, the excretion of the drug is significantly accelerated, and the duration of the drug action is also significantly shortened.
Naproxam Smoking can reduce the concentration of naproxen in the blood and increase its clearance rate, which affects the efficacy of naproxen. This effect is particularly pronounced in patients with angina.
Limianning and diazepam Smoking will diminish the sedative and diazepam effects of Limianning and diazepam. The more the cigarette is smoked, the worse the efficacy.
From this point of view, the effect of smoking on the effects of medicine cannot be ignored. The author here reminds smokers, whether you are healthy or not, for the health of the people around you and your family, advocate a scientific lifestyle, quit all bad habits, gather courage, and quickly say goodbye to tobacco.
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